Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids
Identifieur interne : 000928 ( Main/Exploration ); précédent : 000927; suivant : 000929Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids
Auteurs : Man Zhang ; Yuanyuan Gu ; Shunwei Huang ; Qiuyue Lou ; Qiaomei Xie ; Zhiwei Xu ; Yangfan Chen ; Faming Pan ; Shengqian Xu ; Shengxiu Liu ; Jinhui Tao ; Shuang Liu ; Jing Cai ; Peiling Chen ; Long Qian ; Chunhuai Wang ; Chunmei Liang ; Hailiang Huang ; Haifeng Pan ; Hong Su ; Jian Cheng ; Yuzhou Zhang ; Wenbiao Hu ; Yanfeng ZouSource :
- Journal of Cellular and Molecular Medicine [ 1582-1838 ] ; 2019.
Abstract
The aim of our study was to assess the associations of HSP90AB1 copy number variations (CNVs) with systemic lupus erythematosus (SLE) risk and glucocorticoids (GCs) efficacy, as well as the relationship between HSP90AB1 single‐nucleotide polymorphisms (SNPs) and GCs efficacy. HSP90AB1 CNVs and SLE risk were analysed in 519 patients and 538 controls. Patients treated with GCs were followed up for 12 weeks and were divided into sensitive and insensitive groups to investigate the effects of CNVs (419 patients) and SNPs (457 patients) on the efficacy of GCs. Health‐related quality of life (HRQoL) was also measured by SF‐36 at baseline and week 12 to explore the relationship between CNVs/SNPs and HRQoL improvements in Chinese SLE patients. Our results indicated a statistically significant association between HSP90AB1 CNVs and SLE (
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DOI: 10.1111/jcmm.14410
PubMed: 31124601
PubMed Central: 6653051
Affiliations:
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id="jcmm14410-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Huang, Hailiang" sort="Huang, Hailiang" uniqKey="Huang H" first="Hailiang" last="Huang">Hailiang Huang</name><affiliation><nlm:aff id="jcmm14410-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Pan, Haifeng" sort="Pan, Haifeng" uniqKey="Pan H" first="Haifeng" last="Pan">Haifeng Pan</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Su, Hong" sort="Su, Hong" uniqKey="Su H" first="Hong" last="Su">Hong Su</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Cheng, Jian" sort="Cheng, Jian" uniqKey="Cheng J" first="Jian" last="Cheng">Jian Cheng</name><affiliation><nlm:aff id="jcmm14410-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Yuzhou" sort="Zhang, Yuzhou" uniqKey="Zhang Y" first="Yuzhou" last="Zhang">Yuzhou Zhang</name><affiliation><nlm:aff id="jcmm14410-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Hu, Wenbiao" sort="Hu, Wenbiao" uniqKey="Hu W" first="Wenbiao" last="Hu">Wenbiao Hu</name><affiliation><nlm:aff id="jcmm14410-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Zou, Yanfeng" sort="Zou, Yanfeng" uniqKey="Zou Y" first="Yanfeng" last="Zou">Yanfeng Zou</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31124601</idno><idno type="pmc">6653051</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653051</idno><idno type="RBID">PMC:6653051</idno><idno type="doi">10.1111/jcmm.14410</idno><date when="2019">2019</date><idno 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of glucocorticoids</title><author><name sortKey="Zhang, Man" sort="Zhang, Man" uniqKey="Zhang M" first="Man" last="Zhang">Man Zhang</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Gu, Yuanyuan" sort="Gu, Yuanyuan" uniqKey="Gu Y" first="Yuanyuan" last="Gu">Yuanyuan Gu</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Huang, Shunwei" sort="Huang, Shunwei" uniqKey="Huang S" first="Shunwei" last="Huang">Shunwei Huang</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Lou, Qiuyue" sort="Lou, Qiuyue" uniqKey="Lou Q" first="Qiuyue" last="Lou">Qiuyue Lou</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Xie, Qiaomei" sort="Xie, Qiaomei" uniqKey="Xie Q" first="Qiaomei" last="Xie">Qiaomei Xie</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Xu, Zhiwei" sort="Xu, Zhiwei" uniqKey="Xu Z" first="Zhiwei" last="Xu">Zhiwei Xu</name><affiliation><nlm:aff id="jcmm14410-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Chen, Yangfan" sort="Chen, Yangfan" uniqKey="Chen Y" first="Yangfan" last="Chen">Yangfan Chen</name><affiliation><nlm:aff id="jcmm14410-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Pan, Faming" sort="Pan, Faming" uniqKey="Pan F" first="Faming" last="Pan">Faming Pan</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Xu, Shengqian" sort="Xu, Shengqian" uniqKey="Xu S" first="Shengqian" last="Xu">Shengqian Xu</name><affiliation><nlm:aff id="jcmm14410-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Liu, Shengxiu" sort="Liu, Shengxiu" uniqKey="Liu S" first="Shengxiu" last="Liu">Shengxiu Liu</name><affiliation><nlm:aff id="jcmm14410-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Tao, Jinhui" sort="Tao, Jinhui" uniqKey="Tao J" first="Jinhui" last="Tao">Jinhui Tao</name><affiliation><nlm:aff id="jcmm14410-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Liu, Shuang" sort="Liu, Shuang" uniqKey="Liu S" first="Shuang" last="Liu">Shuang Liu</name><affiliation><nlm:aff id="jcmm14410-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Cai, Jing" sort="Cai, Jing" uniqKey="Cai J" first="Jing" last="Cai">Jing Cai</name><affiliation><nlm:aff id="jcmm14410-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Chen, Peiling" sort="Chen, Peiling" uniqKey="Chen P" first="Peiling" last="Chen">Peiling Chen</name><affiliation><nlm:aff id="jcmm14410-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Qian, Long" sort="Qian, Long" uniqKey="Qian L" first="Long" last="Qian">Long Qian</name><affiliation><nlm:aff id="jcmm14410-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Wang, Chunhuai" sort="Wang, Chunhuai" uniqKey="Wang C" first="Chunhuai" last="Wang">Chunhuai Wang</name><affiliation><nlm:aff id="jcmm14410-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Liang, Chunmei" sort="Liang, Chunmei" uniqKey="Liang C" first="Chunmei" last="Liang">Chunmei Liang</name><affiliation><nlm:aff id="jcmm14410-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Huang, Hailiang" sort="Huang, Hailiang" uniqKey="Huang H" first="Hailiang" last="Huang">Hailiang Huang</name><affiliation><nlm:aff id="jcmm14410-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Pan, Haifeng" sort="Pan, Haifeng" uniqKey="Pan H" first="Haifeng" last="Pan">Haifeng Pan</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Su, Hong" sort="Su, Hong" uniqKey="Su H" first="Hong" last="Su">Hong Su</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Cheng, Jian" sort="Cheng, Jian" uniqKey="Cheng J" first="Jian" last="Cheng">Jian Cheng</name><affiliation><nlm:aff id="jcmm14410-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Yuzhou" sort="Zhang, Yuzhou" uniqKey="Zhang Y" first="Yuzhou" last="Zhang">Yuzhou Zhang</name><affiliation><nlm:aff id="jcmm14410-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Hu, Wenbiao" sort="Hu, Wenbiao" uniqKey="Hu W" first="Wenbiao" last="Hu">Wenbiao Hu</name><affiliation><nlm:aff id="jcmm14410-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Zou, Yanfeng" sort="Zou, Yanfeng" uniqKey="Zou Y" first="Yanfeng" last="Zou">Yanfeng Zou</name><affiliation><nlm:aff id="jcmm14410-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="jcmm14410-aff-0002"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Cellular and Molecular Medicine</title><idno type="ISSN">1582-1838</idno><idno type="eISSN">1582-4934</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The aim of our study was to assess the associations of HSP90AB1 copy number variations (CNVs) with systemic lupus erythematosus (SLE) risk and glucocorticoids (GCs) efficacy, as well as the relationship between HSP90AB1 single‐nucleotide polymorphisms (SNPs) and GCs efficacy. HSP90AB1 CNVs and SLE risk were analysed in 519 patients and 538 controls. Patients treated with GCs were followed up for 12 weeks and were divided into sensitive and insensitive groups to investigate the effects of CNVs (419 patients) and SNPs (457 patients) on the efficacy of GCs. Health‐related quality of life (HRQoL) was also measured by SF‐36 at baseline and week 12 to explore the relationship between CNVs/SNPs and HRQoL improvements in Chinese SLE patients. Our results indicated a statistically significant association between HSP90AB1 CNVs and SLE (<italic>P</italic><sub>BH</sub> = 0.039), and this association was more pronounced in the female subgroup (<italic>P</italic><sub>BH</sub> = 0.039). However, we did not detect association of HSP90AB1 CNVs/SNPs with efficacy of GCs. But we found a marginal association between SNP rs13296 and improvement in Role‐emotional, while this association was not strong enough to survive in the multiple testing corrections. Collectively, our findings suggest that the copy number of HSP90AB1 is associated with SLE susceptibility. But copy number and polymorphisms of HSP90AB1 may not be associated with efficacy of GCs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cai, Jing" sort="Cai, Jing" uniqKey="Cai J" first="Jing" last="Cai">Jing Cai</name><name sortKey="Chen, Peiling" sort="Chen, Peiling" uniqKey="Chen P" first="Peiling" last="Chen">Peiling Chen</name><name sortKey="Chen, Yangfan" sort="Chen, Yangfan" uniqKey="Chen Y" first="Yangfan" last="Chen">Yangfan Chen</name><name sortKey="Cheng, Jian" sort="Cheng, Jian" uniqKey="Cheng J" first="Jian" last="Cheng">Jian Cheng</name><name sortKey="Gu, Yuanyuan" sort="Gu, Yuanyuan" uniqKey="Gu Y" first="Yuanyuan" last="Gu">Yuanyuan Gu</name><name sortKey="Hu, Wenbiao" sort="Hu, Wenbiao" uniqKey="Hu W" first="Wenbiao" last="Hu">Wenbiao Hu</name><name sortKey="Huang, Hailiang" sort="Huang, Hailiang" uniqKey="Huang H" first="Hailiang" last="Huang">Hailiang Huang</name><name sortKey="Huang, Shunwei" sort="Huang, Shunwei" uniqKey="Huang S" first="Shunwei" last="Huang">Shunwei Huang</name><name sortKey="Liang, Chunmei" sort="Liang, Chunmei" uniqKey="Liang C" first="Chunmei" last="Liang">Chunmei Liang</name><name sortKey="Liu, Shengxiu" sort="Liu, Shengxiu" uniqKey="Liu S" first="Shengxiu" last="Liu">Shengxiu Liu</name><name sortKey="Liu, Shuang" sort="Liu, Shuang" uniqKey="Liu S" first="Shuang" last="Liu">Shuang Liu</name><name sortKey="Lou, Qiuyue" sort="Lou, Qiuyue" uniqKey="Lou Q" first="Qiuyue" last="Lou">Qiuyue Lou</name><name sortKey="Pan, Faming" sort="Pan, Faming" uniqKey="Pan F" first="Faming" last="Pan">Faming Pan</name><name sortKey="Pan, Haifeng" sort="Pan, Haifeng" uniqKey="Pan H" first="Haifeng" last="Pan">Haifeng Pan</name><name sortKey="Qian, Long" sort="Qian, Long" uniqKey="Qian L" first="Long" last="Qian">Long Qian</name><name sortKey="Su, Hong" sort="Su, Hong" uniqKey="Su H" first="Hong" last="Su">Hong Su</name><name sortKey="Tao, Jinhui" sort="Tao, Jinhui" uniqKey="Tao J" first="Jinhui" last="Tao">Jinhui Tao</name><name sortKey="Wang, Chunhuai" sort="Wang, Chunhuai" uniqKey="Wang C" first="Chunhuai" last="Wang">Chunhuai Wang</name><name sortKey="Xie, Qiaomei" sort="Xie, Qiaomei" uniqKey="Xie Q" first="Qiaomei" last="Xie">Qiaomei Xie</name><name sortKey="Xu, Shengqian" sort="Xu, Shengqian" uniqKey="Xu S" first="Shengqian" last="Xu">Shengqian Xu</name><name sortKey="Xu, Zhiwei" sort="Xu, Zhiwei" uniqKey="Xu Z" first="Zhiwei" last="Xu">Zhiwei Xu</name><name sortKey="Zhang, Man" sort="Zhang, Man" uniqKey="Zhang M" first="Man" last="Zhang">Man Zhang</name><name sortKey="Zhang, Yuzhou" sort="Zhang, Yuzhou" uniqKey="Zhang Y" first="Yuzhou" last="Zhang">Yuzhou Zhang</name><name sortKey="Zou, Yanfeng" sort="Zou, Yanfeng" uniqKey="Zou Y" first="Yanfeng" last="Zou">Yanfeng Zou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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